on September 24, 2022
Concerned Doctors with Dr. Albert Benavides
Click Here to Enter Albert Benavides Dashboard
on September 24, 2022
WHO HANDED THE KEYS TO FAUCI?!
The Highwire with Del Bigtree The Highwire with Del Bigtree
on September 23, 2022
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factos in Human Lung Microvascular Endothelial Cell and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenisis
In SARS-CoV-2-infected humans, disease progression is often associated with acute respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of the alveolar capillaries. The pathogenesis of these pulmonary complications in COVID-19 patients has not been elucidated. Autopsy study of these patients showed SARS-CoV-2 virions in pulmonary vessels and sequestrated leukocytes infiltrates associated with endotheliopathy and microvascular thrombosis. Since SARS-CoV-2 enters and infects target cells by binding its spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2), and there is evidence that vascular endothelial cells and neutrophils express ACE2, we investigated the effect of S-proteins and cell–cell communication on primary human lung microvascular endothelial cells (HLMEC) and neutrophils expression of thrombogenic factors and the potential mechanisms. Using S-proteins of two different SARS-CoV-2 variants (Wuhan and Delta), we demonstrate that exposure of HLMEC or neutrophils to S-proteins, co-culture of HLMEC exposed to S-proteins with non-exposed neutrophils, or co-culture of neutrophils exposed to S-proteins with non-exposed HLMEC induced transcriptional upregulation of tissue factor (TF), significantly increased the expression and secretion of factor (F)-V, thrombin, and fibrinogen and inhibited tissue factor pathway inhibitor (TFPI), the primary regulator of the extrinsic pathway of blood coagulation, in both cell types. Recombinant (r)TFPI and a thiol blocker (5,5′-dithio-bis-(2-nitrobenzoic acid)) prevented S-protein-induced expression and secretion of Factor-V, thrombin, and fibrinogen. Thrombomodulin blocked S-protein-induced expression and secretion of fibrinogen but had no effect on S-protein-induced expression of Factor-V or thrombin. These results suggests that following SARS-CoV-2 contact with the pulmonary endothelium or neutrophils and endothelial–neutrophil interactions, viral S-proteins induce coagulopathy via the TF pathway and mechanisms involving functional thiol groups. These findings suggest that using rTFPI and/or thiol-based drugs could be a viable therapeutic strategy against SARS-CoV-2-induced coagulopathy and thrombosis. View Full-Text
on September 23, 2022
Aaron Rogers: “Lockdowns Killed Small Businesses.”
Politics is downstream from culture.
on September 22, 2022
Oro-Systemic Health Symposium 2022 – Part 3: Graham Lloyd-Jones – The anatomy of COVID-19
Dr. Graham Lloyd-Jones, Consultant Radiologist at Salisbury NHS Foundation Trust and Director of Radiology Masterclass, describes the nature of COVID-19 lung disease from the perspective of medical imaging. He proposes how understanding the lung disease leads to proposing a direct anatomical route of SARS-CoV-2 viral infection from the mouth to the lungs via the blood
on September 22, 2022
Dr. Jordan Vaughn Interviewed by Phil Williams Rightside Radio
on September 22, 2022
Repentance is the first step to begin recovering – Dr. Peter McCullough
Until 2020, any investigational agent was assumed to be the cause of injury or death, once again science ignored or redefined. The jab causes you to produce a known toxin called the spike protein. Of course the adverse events are due to the experimental biological agent ‘vaccines”. Read moreAlabama WVTM13 Interviews Dr Jordan Vaughn part
on September 22, 2022
Listen to Concerned Doctors Latest Podcast – Redfield Avoids Being Red in the Face
As the information comes to light about just what happened in the early months of 2020, the real power brokers are starting to reveal the inner dysfunction and disputes. A recent interview with Dr. Robert Redfield revealed that he was unaware of all that was happening until the freedom of information act (FOIA) showed the emails and communications between Anthony Fauci and Francis Collins in the critical days of January and February of 2020.
on September 22, 2022
CDC director announces agency overhaul, says it must ‘do better’ after COVID-19 review
It has been a month since the ground breaking news from Director Walinsky that the CDC had failed us the past 2 1/2 years: THERE IS NO OTHER WAY TO READ THIS. As a result, what does that mean to those who have bought into the narrative? How has this changed their perspectives? The public