Lieutenant Colonel (LTC) who is the Brigade Surgeon for the 1st Aviation Brigade in Ft. Rucker, Alabama. She is putting her entire life and career on the line to try to protect the military from the COVID vaccinations. LTC. Theresa Long is an M. D. (University of Texas Health Science Center at Houston Medical School in 2008). She was a Field Surgeon for 10 years and then completed a residency in Aerospace and Occupational Medicine at the U. S. Army School of Aviation Medicine (Ft. Rucker). She trained in the Medical Management of Chemical and Biological Causalities at Ft. Detrick and USAM11RD. She is also board-certified in flight Aerospace Medicine and board eligible in Occupational Medicine.
Currently she is the Brigade Surgeon for the 1st Aviation Brigade at Ft. Rucker, Alabama, where she is responsible for certifying the health, mental and physical ability, and readiness for nearly 4,000 individuals on flight status at Ft. Rucker. She has filed an injunction request (using the Army’s own regulations and procedures as justification) against vaccinating healthy military members with the COVID vaccinations and is recommending the grounding of Army pilots in the Brigade who have already been given COVID vaccinations.
Dr Hayden Childs
In SARS-CoV-2-infected humans, disease progression is often associated with acute respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of the alveolar capillaries. The pathogenesis of these pulmonary complications in COVID-19 patients has not been elucidated. Autopsy study of these patients showed SARS-CoV-2 virions in pulmonary vessels and sequestrated leukocytes infiltrates associated with endotheliopathy and microvascular thrombosis. Since SARS-CoV-2 enters and infects target cells by binding its spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2), and there is evidence that vascular endothelial cells and neutrophils express ACE2, we investigated the effect of S-proteins and cell–cell communication on primary human lung microvascular endothelial cells (HLMEC) and neutrophils expression of thrombogenic factors and the potential mechanisms. Using S-proteins of two different SARS-CoV-2 variants (Wuhan and Delta), we demonstrate that exposure of HLMEC or neutrophils to S-proteins, co-culture of HLMEC exposed to S-proteins with non-exposed neutrophils, or co-culture of neutrophils exposed to S-proteins with non-exposed HLMEC induced transcriptional upregulation of tissue factor (TF), significantly increased the expression and secretion of factor (F)-V, thrombin, and fibrinogen and inhibited tissue factor pathway inhibitor (TFPI), the primary regulator of the extrinsic pathway of blood coagulation, in both cell types. Recombinant (r)TFPI and a thiol blocker (5,5′-dithio-bis-(2-nitrobenzoic acid)) prevented S-protein-induced expression and secretion of Factor-V, thrombin, and fibrinogen. Thrombomodulin blocked S-protein-induced expression and secretion of fibrinogen but had no effect on S-protein-induced expression of Factor-V or thrombin. These results suggests that following SARS-CoV-2 contact with the pulmonary endothelium or neutrophils and endothelial–neutrophil interactions, viral S-proteins induce coagulopathy via the TF pathway and mechanisms involving functional thiol groups. These findings suggest that using rTFPI and/or thiol-based drugs could be a viable therapeutic strategy against SARS-CoV-2-induced coagulopathy and thrombosis. View Full-Text